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"Taylor, Barbara"
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Slimy spawn and other gruesome life cycles
\"If you think all babies are cute, think again! There are disgusting and dreadful stages in the life cycles of many different animals. From tadpoles that eat one another to bloodthirsty bugs, this amazing book describes the gross beginnings of animals that crawl, swim, or fly. Get your hands dirty, too, with some easy (and painless!) experiments.\"-- Provided by publisher.
Book
Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19
In a trial involving 1033 patients hospitalized with Covid-19, the addition of baricitinib to remdesivir was associated with shorter recovery time, particularly among patients receiving high-flow oxygen, and with a 30% higher odds of improvement at day 15 than remdesivir alone. Adverse events were less frequent with the combination therapy.
Journal Article
Stinky skunks and other animal adaptations
\"If you were a hungry coyote, would you brave a skunk's stinky spray for a meal, or would it leave a bad taste in your mouth? Many animals have survival techniques that offend the senses or strike fear in the hearts of predators. From deadly defences to revolting eating habits, this interesting book describes the disgusting and frightening survival techniques of animals. Get your hands dirty, too with some easy (and painless!) experiments.\"-- Provided by publisher.
Book
The Challenge of HIV-1 Subtype Diversity
HIV-1 has evolved multiple mechanisms to elude immune control. The view of virus as classifiable into distinct subtypes needs to reflect the reality of the constant emergence of new strains. This review discusses the implications of subtype diversity in HIV-1 for possible differential rates of disease progression, responses to antiretroviral therapy (including the development of resistance), and vaccine development.
HIV-1 has evolved multiple mechanisms to elude immune control. This review discusses the implications of subtype diversity in HIV-1 for possible differential rates of disease progression, responses to antiretroviral therapy, and vaccine development.
Nearly 27 years after the first reported cases of the acquired immunodeficiency syndrome (AIDS) and 25 years after the discovery of the etiologic agent, effective control of the AIDS pandemic remains elusive. At the root of this challenge is the molecular pathogenesis of human immunodeficiency virus (HIV) type 1 (HIV-1), a virus that has evolved a number of mechanisms to elude immune control. Among the most prominent of these are the heavy glycosylation of the external glycoprotein, which protects neutralization epitopes; the virus' direct targeting of the CD4 molecule expressed by the key T lymphocyte in immune orchestration; integration into . . .
Journal Article
Characterization of Toxin Complex Gene Clusters and Insect Toxicity of Bacteria Representing Four Subgroups of Pseudomonas fluorescens
Ten strains representing four lineages of the Pseudomonas fluorescens group (P. chlororaphis, P. corrugata, P. koreensis, and P. fluorescens subgroups) were evaluated for toxicity to the tobacco hornworm Manduca sexta and the common fruit fly Drosophila melanogaster. The three strains within the P. chlororaphis subgroup exhibited both oral and injectable toxicity to the lepidopteran M. sexta. All three strains have the gene cluster encoding the FitD insect toxin and a ΔfitD mutant of P. protegens strain Pf-5 exhibited diminished oral toxicity compared to the wildtype strain. Only one of the three strains, P. protegens Pf-5, exhibited substantial levels of oral toxicity against the dipteran D. melanogaster. Three strains in the P. fluorescens subgroup, which lack fitD, consistently showed significant levels of injectable toxicity against M. sexta. In contrast, the oral toxicity of these strains against D. melanogaster was variable between experiments, with only one strain, Pseudomonas sp. BG33R, causing significant levels of mortality in repeated experiments. Toxin complex (Tc) gene clusters, which encode insecticidal properties in Photorhabdus luminescens, were identified in the genomes of seven of the ten strains evaluated in this study. Within those seven genomes, six types of Tc gene clusters were identified, distinguished by gene content, organization and genomic location, but no correlation was observed between the presence of Tc genes and insect toxicity of the evaluated strains. Our results demonstrate that members of the P. fluorescens group have the capacity to kill insects by both FitD-dependent and independent mechanisms.
Journal Article
Reptiles
Introduces incredible reptiles, including lizards, snakes, and turtles, describing their unique physical characteristics, life cycles, and survival mechanisms.
Book
Save Nature and Save Ourselves Through Embracing that Shared Sacrifice Can Lead to Shared Success
Nature is not safe from our meddling until we, or at least key leaders, truly believe we are simply a cell in the super-organism called Earth. Here, Taylor discusses how humanity can save nature and thereby save itself.
Journal Article
Mitogenomic phylogenetics of fin whales (Balaenoptera physalus spp.): genetic evidence for revision of subspecies
There are three described subspecies of fin whales (Balaenoptera physalus): B. p. physalus Linnaeus, 1758 in the Northern Hemisphere, B. p. quoyi Fischer, 1829 in the Southern Hemisphere, and a recently described pygmy form, B. p. patachonica Burmeister, 1865. The discrete distribution in the North Pacific and North Atlantic raises the question of whether a single Northern Hemisphere subspecies is valid. We assess phylogenetic patterns using ~16 K base pairs of the complete mitogenome for 154 fin whales from the North Pacific, North Atlantic--including the Mediterranean Sea--and Southern Hemisphere. A Bayesian tree of the resulting 136 haplotypes revealed several well-supported clades representing each ocean basin, with no haplotypes shared among ocean basins. The North Atlantic haplotypes (n = 12) form a sister clade to those from the Southern Hemisphere (n = 42). The estimated time to most recent common ancestor (TMRCA) for this Atlantic/Southern Hemisphere clade and 81 of the 97 samples from the North Pacific was approximately 2 Ma. 14 of the remaining North Pacific samples formed a well-supported clade within the Southern Hemisphere. The TMRCA for this node suggests that at least one female from the Southern Hemisphere immigrated to the North Pacific approximately 0.37 Ma. These results provide strong evidence that North Pacific and North Atlantic fin whales should not be considered the same subspecies, and suggest the need for revision of the global taxonomy of the species.
Journal Article